Congratulations to Dr. Meera Nair and her lab on their recent NIH grant focused on how RELM-α-expressing macrophages mediate host disease tolerance in mucosal infection. The proposed work will be done in collaboration with the Nordgren and Dillman labs at UCR. We’re excited to be spending more time working with the rat parasite Nippostrongylus brasiliensis. We’re also pleased to be extending our collaborative work with Dr. Nair and her lab; this is the third NIH-funded study that we will be working on with Dr. Nair. (https://news.ucr.edu/articles/2020/05/21/scientists-study-how-lungs-respond-worm-infections).
A collaborative study performed by graduate student Tiffany Baiocchi and honors undergraduate student Lauren Braun was recently published in the Journal of Nematology. Previous research had shown that the proportion of Steinernema carpocapsae IJs participating in host-seeking behavior is significantly increased after stimulation by physical contact with host cues. In this follow-up work we found that such physical stimulation results in a three-fold increase in participation by IJs. This effect seems influence the response of nematodes to host-specific odors rather than being a general increase in chemotaxis. Congratulations to Tiffany & Lauren!
Entomopathogenic nematodes (EPNs) are a special guild of insect-parasitic nematodes. What sets them apart from other insect-parasitic nematodes are their ability to rapidly kill their host, and their use of bacteria to facilitate their lifestyle. There are an increasing number of species descriptions that include new species of EPNs, even when the newly described species is not in fact an EPN. A recent study on how to differentiate between EPNs and scavengers was recently published. This work was done by Tiffany Baiocchi, Dennis Chang, and Dihong Lu, in collaboration with visiting scholar Keyun Zhang. Congratulations to the authors, this is a nice study that should prove useful to researchers describing new insect-associated nematodes.
A study done by recent graduates Kassandra Kin and Dr. Tiffany Baiocchi was recently published in Biology. The study investigates the behavioral response of several entomopathogenic nematodes to the odor prenol, which is associated with nematode-infected insects. Since performing this work these scientists have moved on in their careers: After graduating from UCR in June of 2019 Kassandra has accepted a position at NYU’s Stienhardt Teacher Residency program. Tiffany graduated with her Ph.D. in June of 2019 and is currently working as a postdoctoral fellow at Cal State Northridge in the Hong Lab.
Congratulations to Dr. Tiffany Baoicchi!! The Nathan A. Cobb Foundation and the Society of Nematologists awards Tiffany Baiocchi the John M. Webster Outstanding Student Award for 2019. This is the highest award given to a PhD student by the the Society of Nematologists.
Dennis Chang and Tiffany Baiocchi walked and were hooded at UCR’s graduation this summer. They are the first graduate students trained in the Dillman Lab to earn a Ph.D. Dennis will defend his thesis later this year. Tiffany will begin her postdoctoral research in the Hong lab at Cal State Northridge later this summer. Congratulations!
Tiffany Baiocchi, a graduate student in Biochemistry & Molecular Biology, and the first graduate student to officially join the Dillman lab is defending her thesis on Wednesday, May 29th at 1pm in the Genomics auditorium. We invite all to attend and support Tiffany on this momentous occasion.
Congratulations to Dennis Chang, Dihong Lu, and our collaborators Lorrayne Serra and Ali Mortazavi. The paper was published in PLoS Pathogens last week, detailing the conservation of excreted/secreted proteins released by EPNs during parasitic activation.
Sophia & Valentina attended the 60th annual Drosophila Research Conference in Dallas. Adler attended the 2019 Molecular Helminthology conference in San Antonio. We received some positive feedback and new ideas that look forward to working on.
We are excited to learn that our work on nematode-derived toxins will be supported by proof of concept funding by UCR. “We look for projects that promise to solve one or more urgent problems. We help those researchers with a little seed funding to move their work closer to commercialization,” explained Mark Leibowitz, interim director of UCR’s Entrepreneurial Proof of Concept and Innovation Center, or EPIC.”
“Adler Dillman, an assistant professor of nematology, received $30,000 to identify the proteins some nematodes secrete when they infect an insect and kill it. Dillman plans to use the toxin in a pesticide, or genetically modify crops to produce the protein and become naturally insect-resistant. Most corn and cotton in the U.S., for example, has been genetically modified to produce a protein called BT toxin, originally found in a type of bacteria. But insects are starting to resist BT toxin, and the nematode-derived toxin could serve as a supplement or alternative.”